This suggests that the acute consequence of losing the tumor-intrinsic PD-L1 function is the increased destruction of Snail proteins, whereas the long-term or permanent loss of PD-L1 could further trigger the degradation of Snail mRNAs and achieve a more stable interruption of the EMT status and EMT-associated aggressiveness, such as metastasis and treatment resistance. Here, SNAI1 is linked to neoplasm.