In the past years, the role of NRP-1 in cancer progression has gained significant interest with studies showing a tumor promoting or prognostic role in several malignancies including pancreas (Ben et al. 2014), liver (Xu and Xia 2013), gastric (Kang et al. 2020), colon (Parikh et al. 2004), lung (Roche et al. 2002) and breast cancer (Ferrario et al. 2006). This evidence concerns the gene NRP1 and breast carcinoma.