Performing this analysis for the COVID-19 patients demonstrated clear B- and T-cell clusters, defined by expression of TCF7, LEF1 (clusters 0 and 1), CD74, CD79A (clusters 2 and 3), IL7R (cluster 4) and CCL5, NKG7, GNLY (cluster 6) (Supplementary Figure S3B). Here, LEF1 is linked to COVID-19.