CCND1 and non-small cell lung carcinoma: It is found that NSCLC lowly expressed circRNA-ITCH which could be used as a sponge of miR-7 and miR-214, reducing their expression levels, reducing the regulatory effect of miRNA on downstream target genes, resulting in downregulation of b-catenin, c-myc, and cyclinD1, and then inhibiting the activation of Wnt/b-catenin signal in NSCLC cells [14].