In the current study, we aimed to elucidate the efficacy of serum liver fibrosis markers (fibronectin, hydroxyproline, and hyaluronic acid) and their respective indices (HA index, Hyp index, and FN index) and vitamin D status in predicting malnutrition associated with liver fibrosis in CHC patients and to investigate their association with the value of current clinical malnutrition assessment tools (SGA, BMI, MAMC, and HGS). This evidence concerns the gene FN1 and nutritional deficiency disease.