TNF and cryohydrocytosis: In addition, in this study, significant correlation was reported between estimated SGA scores and severity of liver fibrosis as measured by increased liver dysfunction, AST, ALT, TNF-α, AFP, bilirubin, INR; a decline in the values of BMI, WHtR, and albumin; and a significant increase in the levels of Hyp, HA, and FN and their respective indices (APRI, Hyp, HAI, and FNI) in CHC patients with significant fibrosis and cirrhosis.