FN1 and nutritional deficiency disease: Although liver fibronectin, hydroxyproline, hyaluronic acid, liver function, and platelet counts and their respective indices (APRI, HA index, Hyp index, and FN index) as noninvasive biomarkers were reported in evaluation of liver fibrosis [25, 26, 28, 34, 35], little is known about the importance of parameters as noninvasive biomarkers in predicating and evaluation of malnutrition associated with severe hepatic dysfunction.