In addition, in this study, significant correlation was reported between estimated SGA scores and severity of liver fibrosis as measured by increased liver dysfunction, AST, ALT, TNF-α, AFP, bilirubin, INR; a decline in the values of BMI, WHtR, and albumin; and a significant increase in the levels of Hyp, HA, and FN and their respective indices (APRI, Hyp, HAI, and FNI) in CHC patients with significant fibrosis and cirrhosis. The gene discussed is TNF; the disease is Hepatic fibrosis.