The contemporary production of reactive oxygen species generated during reoxygenation periods leads to activation of nuclear factor-kB (NF-kB) signaling that is associated with inhibition of apoptosis, synthesis/secretion of proliferation molecules, matrix metalloproteases, and angiogenetic molecules such as vascular endothelial growth factor (VEGF), which in turn enhance angiogenesis, tumor cell invasion, and metastatization [19]. Here, NFKB1 is linked to neoplasm.