Whilst the renin-angiotensin system is mainly involved in the regulation of blood pressure and body fluid balance (Ager et al., 2008[1]), there are several studies showing that renin-angiotensin system also regulate different aspects of tumor progression, including: cell proliferation, angiogenesis, inflammation, and apoptosis (Deshayes and Nahmias, 2005[15]). This evidence concerns the gene REN and neoplasm.