REN and neoplasm: Aberrant activation of renin-angiotensin system is found in different malignancies and is associated with tumor metastasis, invasion, migration, and angiogenesis (Ager et al., 2008[1]; Suganuma et al., 2005[48]; Juillerat-Jeanneret et al., 2004[28]; Kikkawa et al., 2004[29]; Dinh et al., 2001[17]).