CDH1 and lung cancer: In contrast, β3 integrin knockdown in H1975 cells, a human lung cancer cell line with endogenous αvβ3 integrin expression (Fig. 2h) and partial EMT phenotype26, led to the formation of colonies with epithelial morphology (Fig. 2i), decreased expression of vimentin and ZEB1, and slightly increased expression of E-cadherin (Fig. 2h).