Epithelial stromal interaction 1 (EPSTI1) is an interferon (IFN) response gene37, LAIR-1 may play a relevant role in the mechanisms controlling IFNα production by dendritic cells both in normal and pathological innate immune responses38, IRS1 expression is altered in SLE mice39, and the frequency of the IGHV3 gene family has been assessed over glucocorticoid time treatment40. Here, LAIR1 is linked to systemic lupus erythematosus.