However, in subgroups created based on baseline UAE tertiles, for subjects in the lower UAE tertile (UAE < 6.6 mg/24 h) DKK3 plasma levels were significantly associated with new-onset CKD, also after correction for age, sex and after correction for the multivariable model or the clinical model (Supplemental Table S6). The gene discussed is DKK3; the disease is chronic kidney disease.