DKK3 and chronic kidney disease: Again, in crude Cox proportional hazards regression analysis, DKK3 levels were significantly associated with new-onset CKD (HR: 1.68 [1.38–2.05] per DKK3 doubling, P < 0.001) (Table 5), but after age-adjustment this association was no longer significant (HR: 1.03 [0.80–1.31] per DKK3 doubling, P = 0.832) (Table 5).