Consistent with this hypothesis, we noticed that indeed a subset of differentially expressed genes in lung cells of patients infected with SARS-CoV-2 is also the shared target of PAK- and vitamin D-modulated genes and such genes were coinfluenced by not only a defective vitamin D endocrine system but also PAK1 upregulation associated with SARS-CoV-2-infection; thus, they are involved in SARS-CoV-2 pathobiology. The gene discussed is PAK1; the disease is infection.