In this context, previous studies have suggested a role of PAK-dependent modulation of actin polymerization in the regulation of FGF2326,27, a modifier of CYP27B1 and CYP24A1 in the vitamin D endocrine system, and the vitamin D endocrine system have been suggested to inhibit the levels of RAC (a positive regulator of PAK1 activation) in endometrial cancer cells27. The gene discussed is CYP27B1; the disease is endometrial cancer.