PLOD2 and cancer: More recent reports have shown that not only these genes but also that encoding LH2, i.e. procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2), is increased in breast31,32, sarcoma33, lung34, and glioma35 cancer models, indicating that the type of cross-linking is switched to a stable Hylald-derived pathway.