DNase X−/− cells are not completely resistant to infection, supporting our hypothesis that TRP120 as an adhesin initiates Wnt-dependent signaling that either directly or indirectly facilitates infection through initiation of phagocytosis; autophagy modulation, which our lab has previously investigated; or immunosuppression, which has been investigated in relation to other intracellular pathogens (61, –, 64). Here, DNASE1L1 is linked to infection.