TNF and neoplasm: Consistent with the MC38 tumor model (figure 2A, B), RagD-deficient antigen-specific CD8+ T cells failed to suppress tumor growth (figure 2F–H), as well as a decrease in the proportions of IFN-γ+ TNF-α+ polyfunctional and IFN-γ-secreting, TNF-α-secreting and GZMB-secreting subpopulations from CD8+ TILs (figure 2I, J).