To mitigate the effects of tumor heterogeneity in individual mice, we used a co-adoptive transfer system in which Rragd−/− CD45.2 OTI and Rragd+/+ CD45.1.2 OTI CD8+ T cells were transferred at an equal ratio into the same MC38-OVA tumor-bearing Rag1−/− hosts (figure 3D, E). The gene discussed is RRAGD; the disease is neoplasm.