Although targeting hexokinase with 2-DG alone is generally ineffective, it can sensitize AML cells to other drugs that affect mitochondria, including cytarabine, inhibitors of complex I of the ETC (such as rotenone), the mitochondrial uncoupler CCCP, and BH3-mimetic inhibitors of Bcl-2, like ABT-737 [13, 34, 35] (see Figs. 1 and 2 for an overview of druggable mitochondrial targets). This evidence concerns the gene BCL2 and acute myeloid leukemia.