Computational analysis demonstrated that a novel tumor suppressor, 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), can competitively inhibit PFKFB3, and decreases intracellular concentrations of fructose 2,6-bisphosphate; this subsequently decreases glycolytic flux in various tumor models [37]. The gene discussed is PFKFB3; the disease is neoplasm.