PFK1 is allosterically activated by the compound fructose 2,6-bisphosphate, which is overproduced in many cancer types by the overexpression of PFKFB3, a dual function 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase that is a therapeutic target itself [36]. Here, PFKFB3 is linked to cancer.