We pinpoint multiple COVID-19-interacting genes for which genetic regulatory variants associate with immune- or respiratory-related outcomes, including the interferon-induced transmembrane protein 3 (IFITM3), endoplasmic reticulum metallopeptidase 1 (ERMP1), and methylphosphate capping enzyme (MEPCE), making them strong candidates for host genetic risk factors. Here, MEPCE is linked to COVID-19.