Overexpression of the MCL-1 protein or amplification of the MCL-1 gene protects cancer cells from apoptosis and decreases their sensitivity to commonly used anticancer drugs, which has emerged as a resistance mechanism against multiple anticancer therapies, including radiotherapy, chemotherapy, and BH3 mimics targeting BCL-2/BCL-XL [10, 11]. This evidence concerns the gene BCL2 and cancer.