Combined inhibition of MCL-1 and BCL-xL by S63845/S64315 plus Navitoclax [149] or the combination of MCL-1 and BCL-2 by S63845/S64315 plus ABT-199 [150] synergistically induces extensive death in advanced/refractory melanoma cell lines both in vitro and in vivo. This evidence concerns the gene BCL2 and melanoma.