MAPT and Alzheimer disease: Cerebrospinal fluid (CSF)-based tests for total-tau (t-tau), phospho-tau (p-tau) and amyloid β (Aβ42) are included in the diagnostic criteria of AD [4], while 14-3-3 protein and PrPSc detection by the real-time quacking induced conversion (RT-QuIC) are included in the diagnostic criteria of CJD [5, 6].