Significant differences in AUC values between Nfl and t-tau for each comparison indicates high specificity for t-tau in the discrimination of CJD cases from the other diagnostic groups, while Nfl resulted in a less specific test with a good diagnostic value in the discrimination of all conditions associated to dementia from HC and NND (Fig. 1c, Table 2). The gene discussed is TBXT; the disease is Creutzfeldt Jacob disease.