INSR and diabetic kidney disease: In addition, Egr‐1 is able to augment its function in DKD inflammation by interacting with TGF‐β, and the overexpression of Egr-1 can also upregulate the lncRNA Arid2-IR level which contributes to ECM accumulation in DKD [125], in support of a complicated potential mechanism of metabolic memory in DKD.