Marioni et al. have recently conducted a GWAS using self-reported parental history of AD (i.e., AD-by-proxy) and undertook SMR integrating with eQTL and meQTL data from dorsolateral prefrontal cortex, identifying highly significant associations with expression of CR1, TOMM40 and KAT8 amongst other genes [46]. This evidence concerns the gene CR1 and Alzheimer disease.