It is shown here that after adjusting for G6PD deficiency (carriage of the A− G6PD allele) or sickle cell trait (Hb-A/S allele), both associated with resistance to blood stage malaria infection, carriers of the IFNL4 TT/TT genotype had a reduced risk for malaria infection. This evidence concerns the gene IFNL4 and hyperinsulinemic hypoglycemia, familial, 4.