Carriage of the IFNL4-dG allele is clearly not providing protection against HCV [4, 7–9], respiratory infections [11], gastrointestinal infections [29], human coronavirus, HCoV-229E or MERS-CoV [30], and now this study shows similar results for P. falciparum malaria in children. This evidence concerns the gene IFNL4 and digestive system infectious disorder.