MME and obesity due to melanocortin 4 receptor deficiency: Using a preclinical model of obesity and pre-diabetes, here we report that sacubitril/valsartan (sac/val; LCZ696), a combination of Ang II receptor blocker and neprilysin (NEP) inhibitor (ARNi), improved echocardiographic parameters of ventricular stiffness that were impaired in untreated ZO rats.