Later, she was treated with transnasal transsphenoidal resection for the pituitary mass, and the pathology findings suggested pituitary adenoma (Fig. 2). She was then prescribed with methylprednisolone 40 mg once after pituitary surgery, and her cortisol level (8 am-4 pm-12 pm): 143.13μg/L-47.12μg/L-5.93μg/L, adrenocorticotropic hormone (ACTH) level (8 am-4 pm-12 pm): 33 pg/mL-18.8 pg/mL- < 5 pg/mL, 24-h urine cortisol level was 388μg, as well as gonadotrophins and thyroid hormones were all in the normal range at that period. Here, POMC is linked to pituitary gland adenoma.