In this study we analyzed the medical records of 11,138 NSCLC patients in the Mount Sinai Health System electronic health record (EHR) database, 249 of whom were treated with the PD-L1/PD-1 ICIs nivolumab, atezolizumab, or pembrolizumab for metastatic disease at any line of therapy. This evidence concerns the gene CD274 and non-small cell lung carcinoma.