Also, functional in vitro and in vivo analyses for TACSTD2 in other human tumor entities like lung adenocarcinoma, HCC and cholangiocarcinoma, consistently demonstrated that silencing of TACSTD2 gene expression results in a significant increase of tumor growth [34] and leads to cell proliferation and migration [33, 35]. This evidence concerns the gene TACSTD2 and cholangiocarcinoma.