TLR activation of ERK1/2 and p38α in macrophages is mediated by TPL‐2 (tumour progression locus 2, also known as MAP3K8), a MAP 3‐kinase that directly phosphorylates and activates the MAP 2‐kinases MKK1, 2, 3 and 6 (Gantke et al,2012; Pattison et al,2016). The gene discussed is MAP3K8; the disease is neoplasm.