At the protein level, however, besides TNF-α, also IL-1β was not detectable in supernatants of CF, while IL-6 and IL-8 production was significantly lower after siMDA5- and siRIG-I-knockdown than after siTLR3- and siMock-knockdown (Fig. 5c). The gene discussed is CXCL8; the disease is cystic fibrosis.