Since TLR2 was not expressed neither in CF nor in IHCM (Fig. 1a), it was not surprising that stimulation with Pam3CSK4 did not induce any cytokine expression at the RNA level in CF and in the IHCM, while just a slightly increase of IL-8 in CF at the protein level was observed (Fig. 2a and b). The gene discussed is TLR2; the disease is cystic fibrosis.