To conclude, this study evidenced that adMSC-derived exosomal miR-671 directly targets the TGFBR2/Smad2 axis and alleviates OGD-induced damage on mouse cardiomyocytes in vitro and myocardial injury in model mice with MI (Fig. 8). Here, TGFBR2 is linked to myocardial infarction.