The influence of PRNP codon 129 on CSF sTREM2 (higher concentrations in MM compared to VV cases) is different to that reported for neuronal damage markers such as CSF t-tau and 14-3-3, which display significantly lower values in CJD MV cases compared to homozygotes [19, 27], and is explained by the less severe phenotype and longer disease duration of CJD MV cases. Here, PRNP is linked to Creutzfeldt Jacob disease.