IL1B and Alzheimer disease: A systematic inflammation apparently seems to play a significant role in the onset and progression of AD.11,16,34 Elevated systemic levels of inflammatory mediators, i.e. interleukin (IL)-1β, IL-6 und tumor necrosis factor α (TNF-α), have been demonstrated to be associated with the neuronal degeneration found in AD.3,26 Many studies indicate that an infection triggering an inflammatory response may be linked to AD.18,20,39