MAPT and Alzheimer disease: Around 110 years later, dementia – with Alzheimer’s Disease (AD) being most frequent – is a challenge for health-systems worldwide.41 Neuropsychological testing and determination of certain markers in cerebrospinal fluid (CSF), such as total tau-protein and β-amyloid1-42 (Aβ1-42), allows distinguishing between different forms of dementia.9,15