In this context, periodontitis has gained increasing attention.13,19,21,36 It has been suggested that the production of Aβ1-42 plaques and extracellular tau tangles are triggered via a systematic inflammatory reaction.39 Although periodontal disease has been documented in all forms of dementia, to date, no study has analysed the differences between AD and noAD/DEM. Here, MAPT is linked to Alzheimer disease.