AKT1 and neoplasm: In recent years, many signaling pathways related to regulation of tumor are confirmed to be associated with cardiac disease, such as mTOR‐Akt signaling pathway [34], JAK‐STAT signaling pathway [35], as well as NF ‐ κ B (NF ‐ κ b) signaling pathway [36], which typically play a key role in the development of tumors related inflammatory response.