CXCL12 and cancer: In this study, combined with the results of KEGG and PPI network results, we found that CXCL12 plays a key role in the emergence and development of IS through two signaling pathways: pathways in cancer and Thyroid hormone synthesis signaling pathway, which may reveal that CXCL12 is a small but important molecular protein that can nest cells to circulate towards the injured niches, and itself is able to induce the progenitor cells to nest and migrate to the lesion site to promote the repairing and maintenance of homeostasis [39].