A recent study used the Gαq‐selective inhibitor YM‐254890 and the adenylate cyclase inhibitor MDL‐12330A to demonstrate that, under normal circumstances, GLP‐1‐induced insulin secretion is primarily Gαs‐mediated, but Gαq plays a more important role when beta cells are chronically depolarised, for example, with sulphonylurea treatment or sustained hyperglycaemia (Oduori et al., 2020). This evidence concerns the gene GNAQ and Hyperglycemia.