In the present study, we detected changes in the biochemical indices and levels of miR-34a, SIRT1, HIF-1a, Egr-1, and TGF-β and explored whether liraglutide plays a protective role in DN rats through the regulation of the miR-34a/SIRT1 pathway. The gene discussed is TGFB1; the disease is liver dysplastic nodule.