IGHM and necrotizing enterocolitis: urther analysis revealed that B cell-specific genes, such as TNFRSF17, IGHG1, IGHA1, SLC15A2, IGHM, IGKC, and CR2, macrophages M1-specific genes, such as CXCL9, CXCL10, and CXCL11, and plasma cells-specific genes, such as TNFRSF17, MZB1, and EAF2, were highly upregulated in NEC (Figure 2(b)).