Besides, PPI network analysis indicated that 6 hub genes including PABPC4 (Poly(A) Binding Protein Cytoplasmic 4), JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit), HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A), GSK3B (Glycogen Synthase Kinase 3 Beta), RNF4 (Ring Finger Protein 4), and GAK (cyclin G associated kinase) may be used as new targets in dabrafenib-resistant melanoma which had higher degrees of interaction. This evidence concerns the gene GAK and melanoma.