The mutational spectra of SCLC were dominated by missense, where indel and frameshift mutations occurred predominantly in TP53, RB1, and KMT2D. There were two mutation hotspots, c.832C > T (p.P278S) and c.1548G > A (p.W516X), observed in TP53 and RB1, respectively (Table S2). The gene discussed is TP53; the disease is small cell lung carcinoma.