F8 and neoplasm: In the first study, DNA nanotechnology using DNA nanorobots capable of smart opening at the tumor site to reveal hidden thrombin inside used for selective on-demand induction of tumor vascular infarction.10 Likewise, a two-component system is described where induction of coagulation cascade by either heated gold nanorods or tTF-RGD was exploited to broadcast the signals of coagulation to the receiving nanoparticles coated with fibrin binding peptide or FVIII substrate.