Apoptosis was investigated by Annexin V/PI staining, while cancer cells were treated by sole purified α-defensin (15 μg/mL), sole nisin (75 μg/mL), and combinations of these two peptides at their best an half best effective doses (15-75 μg/mL and 7-35 μg/mL). Here, ANXA5 is linked to cancer.