It is demonstrated that anti-inflammatory cytokines such as IL-10 (secreted from Th2 cells) exhibited a protective impact against diabetes progression in the animal model.26 It was proposed that IL-10 decreased in T2DM, which is associated with risk of DM.27,28 In this regard, it is established that it can modulate or inhibit the production of TNF-α and IL-6.29 It was also mentioned that the high IL-10 concentrations inhibit the progression of T2DM and its metabolic syndrome by reducing the results of the inflammatory response such as TNF-α and IL-6.30 This evidence concerns the gene TNF and metabolic syndrome.