CASP7 and B-cell non-Hodgkin lymphoma: For example, disruption of caspase-7 is not lethal in chicken B cell lymphoma line DT40 and mouse embryonic fibroblasts cells.29,30 Nevertheless, the caspase-7 gene deletion is reportedly lethal in mice.31,32 On the same token, we found that homozygote caspase-7 deletion seemed to be lethal in the CHO cell line, which begets more study.