A recent study indicated that mir-34a inhibited the invasion and migration of SW620 cells by blocking vimentin and increasing early growth response protein 1 (EGR1).24 MiRNA-1258 elicits tumor-suppressive effects and suppresses the proliferation and migration of human CRC Cells by inhibiting cyclin-dependent kinase regulatory subunit 1B (CKS1B).36 Also, miR-501-3p promotes CRC progression by activation of Wnt/β-catenin signaling and through reducing expression of their target genes, cyclin D1 and c-Myc in vitro. The gene discussed is CCND1; the disease is colorectal carcinoma.