TYMS and colorectal carcinoma: Mir-19b, miR-34, and miR-192/215 are other miRNAs determining the resistance to 5-FU.91-93 Some of the miRNAs linked to the oxaliplatin resistance are miR-20 and miR-1915.94,95 Mir-433 sensitizes HeLa cell to 5-FU by reducing TYMS expression, and is downregulated in CRC tissues and cell lines.