PTEN and colorectal carcinoma: For more than 50 years, advanced CRC patients have been using fluoropyrimidine-based chemotherapeutic agents such as 5-FU.63 Nishida et al. found that the expression of miR-10b is a strong indicator for measuring the sensitivity to the conventional chemotherapy regimens based on 5-FU.83 Mir-17-5p results in chemoresistance in CRC patients by inhibiting the PTEN gene through binding to two regions in the 3’UTR region of this gene.