Svoboda et al. reported that let-7e, miR-99a, miR-215, miR-450b-5p, and miR-196b are involved in the CRC response to chemotherapy.97 It was reported that mir-99 impedes pro-survival/anti-apoptotic pathways through affecting Bcl-2 and mTOR targets.98 The upregulation of miR-592 has been observed in CRC patients with a healthy MMR (Mismatch Repair) system as compared to patients with defective MMR system. Here, BCL2 is linked to colorectal carcinoma.