TP53 and colorectal carcinoma: Mir-29c also limits cell migration by increasing epithelial markers such as E-cadherin and β-catenin and reducing mesenchymal markers such as fibronectin and vimentin which cause MET-related morphologic changes.17 Mir-29c-3p is a critical target of the P53 gene and regulates the expression of Pleckstrin Homology-Like Domain Family Member 2 (PHLDB2), which is involved in colon cancer metastasis in CRC patients.58