This miRNA reduces the apoptotic effect of these drugs.46 According to the findings reported by Nakajima et al, let-7 and miR-181b are linked to the response to 5-FU treatment.89 MiR-203 influences the response of CRC cells to 5-FU by inhibiting TYMS, and inhibits tumor growth.90 It also positively regulates the CRC cell responses to paclitaxel, which affects the cell cycle, by reducing AKT. The gene discussed is AKT1; the disease is colorectal carcinoma.