This miRNA reduces the apoptotic effect of these drugs.46 According to the findings reported by Nakajima et al, let-7 and miR-181b are linked to the response to 5-FU treatment.89 MiR-203 influences the response of CRC cells to 5-FU by inhibiting TYMS, and inhibits tumor growth.90 It also positively regulates the CRC cell responses to paclitaxel, which affects the cell cycle, by reducing AKT. Here, TYMS is linked to colorectal carcinoma.