Mir-218 induces the apoptosis of SW1417 cells by increasing caspase-8 expression and inhibiting cellular c-Fas-associated death domain-like interleukin-1β-converting (c-FLIP) regulator.32 Mir-222 increases cell proliferation and migration and reduces apoptosis.77 Mir-223 improves the cellular proliferation of CRC cells as well as their migration and invasion capabilities.78 Mir-224 increases cell proliferation and tumorigenesis by suppressing two tumor suppressors named PHLPP1 and PHLPP2 in vitro and in vivo. This evidence concerns the gene PHLPP2 and neoplasm.