In contrast, Mir-23a expression is shown to suppresses the apoptosis induced by 5-FU through the APAF1/caspase9 pathway in the HCT-116 and HT-29 cell lines.39 Mir-27a can block cell proliferation, colonization, and growth of CRC tumors by targeting SGPP1, Smad2, and STAT3. The gene discussed is STAT3; the disease is colorectal carcinoma.