According to the results of enrichment analysis of KEGG pathway, we found pathways closely related to the pathological process of osteoporosis, mainly including AGE-RAGE signaling pathway in diabetic complications, osteoclast differentiation, MAPK signaling pathway, Wnt signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, and TNF signaling pathway. Here, TNF is linked to osteoporosis.