LZTR1 and schwannomatosis: This means that if the effect of a whole-gene deletion were the same as a loss-of-function point variant, then, due to the 1 in 3–6,000 frequency of 22q11.2DS, we should expect to find one 22q11.2 deletion for every 12 to 25 LZTR1-associated schwannomatosis diagnoses.