WFS1 and Wolfram syndrome 2: Both genes responsible, i.e., WFS1, for Wolfram syndrome type 1, and CISD2, for Wolfram syndrome type 2, are inherited with an autosomal recessive (AR) mode of inheritance and encode for wolframin and CDGSH iron-sulfur domain 2 proteins, respectively, and have high expression in brain, lung, heart, and pancreas [2, 3].