SOD3 and stroke disorder: These results revealed that the medical history was mostly similar between the SOD3 p.R231G non-carriers and heterozygotes in the entire, Very Old, and Centenarians, suggesting that the approximately tenfold difference in the plasma EC-SOD concentration among the SOD3 p.R231G genotypes was not affected by medical history including DM, stroke, coronary heart CHD, CKD, and pneumonia in the Very Old and Centenarians.