NPM1-mutated AML without FLT3-ITD or with FLT3-ITD low allelic ratio (<0.5; FLT3-ITDlow) belongs to the ELN favourable risk category whilst NPM1-mutated AML with FLT3-ITD high allelic ratio (≥0.5; FLT3-ITDhigh) falls into the intermediate risk group [6]. Here, NPM1 is linked to acute myeloid leukemia.