In contrast, CRISPR-SAM oe-BMP1 in AsPC1 cells did not alter the orthotopic xenograft primary tumor weight or lung metastasis (Supplementary Fig. 4A–E) and did not change the ColI protein level in cultured cells (Supplementary Fig. 4F, G), nor in the xenograft tumors by IHC of tumor sections (Supplementary Fig. 4H, I), WB of enriched ECMs (Supplementary Fig. 4J, K) or Hypro measurement of collagen levels (Supplementary Fig. 4L). This evidence concerns the gene BMP1 and neoplasm.