As expected, CDH1 mutations were highly enriched in the invasive lobular carcinoma (ILC) subtype of breast cancer35 (two-sided Fisher’s exact, p value = 4.4 × 10−38), which was more prevalent in older patients (two-sided Wilcoxon rank sum test, p value = 0.00081) (Supplementary Fig. 10c, d). This evidence concerns the gene CDH1 and invasive lobular breast carcinoma.