To exclude the possibility that germline predisposition mutations in some patients may cause such a high number of age-DEGs and age-DMGs in cancers of the female reproductive system, we excluded samples harbouring germline mutations in BRCA1, BRCA2 and TP53 as previously identified42 from the breast, ovarian and endometrial cancer cohorts and repeated the multiple linear regression analysis. Here, BRCA1 is linked to endometrial cancer.