TNF and rheumatoid arthritis: In line with this, SNA binding revealed a higher expression of α2-6 sialic acid in the synovium of RA patients in remission after c-DMARDs + TNF-inhibitor treatment (Fig. 8b) compared with OA and naive (not exposed to biologic DMARDs) RA synovium, supporting our conclusion of sialylation being an anti-inflammatory factor not only in the mouse model but also in human RA.