MUC2 and colon mucinous adenocarcinoma: Interestingly, goblet-specific mucin 2 (MUC2) was absent in most PDOs but massively produced in the organoid derived from the mucinous adenocarcinoma of patient 13 (Fig. 1c, third and fourth rows), consistent with the histopathological features of the clinical specimen (Supplementary Table 1).