WWTR1 and colorectal carcinoma: Notably, the percentage of enhancer regions bound by TAZ increased with the level of conservation between PDOs (Fig. 4g) up to 40% in the highly conserved enhancers (n = 195, in 8 to 10 PDO lines, Supplementary Data 8) indicating a role for TAZ in regulating a sizeable fraction of the shared CRC enhancerome.